Over the past week I managed to catch a couple episodes of League of Super Evil on Cartoon Network. (If you haven’t seen the show and haven’t put it together yet, that acronym is LOSE.) It inspired me for a wonderful game. Take your favorite super hero system. Have players generate super villains, but give them extremely low points to create their characters and/or make their powers weak and ridiculous. Don’t run adventures about stealing lots of money or trying to take over the world. Instead, run adventures about petty things like trying to steal cable, or ordering a pizza and deliberately delaying the delivery guy so that you get the pizza free.
The primary idea here is that the characters should be pathetic enough that even minor things are difficult to accomplish for them. This would obviously be a light-hearted comedy game. I’m sure you could take lots of inspiration from Paranoia, Hol, and other games with a lot of ridiculous comedy and seething sarcasm.